Turning “low-irritation, verifiable, traceable” into a working process
In 2013, the Nobel Prize in Physiology or Medicine established the cellular “vesicle trafficking” mechanism—essentially the instruction manual for how cells package and deliver signals. That insight helps us understand and modulate exosome formation and release, opening possibilities in skin and aesthetic care. Exosomes have since been widely explored as one of the most promising ways to overcome long-standing bottlenecks in regeneration and repair.
TL;DR
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Yes—in sensitive/Reactive skin, use exosomes for gentle stabilization. For first-timers, patch test 24–48 h (behind ear/inner forearm) and follow professional guidance.
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Our format is freeze-dried powder + dedicated diluent (EXO-Lyospheres™). Fresh-mix, one vial = one session; if you must split, 2–8 °C and finish within 48 h.
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Microneedling/energy devices are an advanced step for sensitive skin—prefer 1–2 weeks of non-invasive stabilization first, then proceed only after a clinic evaluation.
Why this is friendlier to sensitive skin
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Cleaner by design: freeze-drying “locks” activity, reducing reliance on heavy preservatives/over-built stabilizers.
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Skin-like diluent: isotonic + skin-friendly pH + buffer to minimize sting and heat.
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Standardized dose: one vial = one use limits repeated opening and contamination.
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Fresh-Batch 48h: within 48 hours of order we allocate the latest released batch, print per-vial labels, and ship with temperature awareness; every vial’s LOT/Vial-ID links to a Trace Page (COA snapshot, temp notes).
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Claim discipline: we focus on soothing, hydration, and barrier support—cosmetic scope only.
First-time users: a 3-step plan
Step 1|Patch test (T−1 to T−2)
Dry the site → apply a pea-size amount of freshly mixed solution over a coin-size area → observe 24–48 h.
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Okay to proceed: faint, short-lived pinkness/tightness that settles within 24 h.
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Pause & consult: persistent burning, widespread erythema, weeping, papules, or worsening itch.
Step 2|First full-face (D0, non-invasive)
Gentle cleanse (<30 s) → thin layer / 10–15 min soak of freshly mixed exosomes → light repair cream.
That night: no strong actives. Outside: broad-spectrum/physical-leaning SPF + shade.
Step 3|Consolidate (D1–D7)
Use 1–2×/week (thin layer or 10–15 min soak). Other days keep it cleanse → hydrate → repair → SPF.
Avoid: AHA/BHA/peels, strong retinoids or Rx tretinoin, ≥15% L-AA vitamin C, high-alcohol/strong fragrance toners, hot steam/sauna, vigorous rubbing.
Considering microneedling/energy later (the sensitive-skin pathway)
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Prerequisite: 1–2 weeks of calm baseline with the non-invasive routine; visible redness/itch should be clearly improved.
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Microneedling guardrails (professional only): typical upper bound 0.25–0.3 mm, 4–6 passes/zone in a cross-hatch, stopping at uniform blush (don’t chase bleeding). Within 0–60 min post-procedure: fresh-mix full vial → 10–15 min calming occlusion.
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72-hour rule: hydrate + repair + SPF only; re-introduce actives ≥D4–D7.
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Cadence: every 7–10 days; Pro/Max/Ultra cover 1/2/3 sessions; sensitive skin should start with Pro.
Pairing list—what plays well (and what doesn’t)
Works well (highest → lower priority):
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Isotonic mists
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HA/polysaccharide hydrators
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Ceramides / squalane / cholesterol / panthenol repair creams
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Low-% niacinamide (2–5%)
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Gentle peptides
Hold off on:
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AHA/BHA/salicylic peels
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Strong retinol/retinal or Rx tretinoin
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≥15% L-AA vitamin C
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Scrubs/cleansing brushes, hot steam/sauna
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High-alcohol toners and heavy fragrance
Dose & storage
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1 freeze-dried vial + 1 diluent = 1 standard session. Aim to finish at once.
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If splitting is unavoidable: refrigerate 2–8 °C, use within 48 h. Discard if you see off-odor, distinct discoloration, flocs/strings, or a broken seal.
A printable 7-day mini-calendar (sensitive skin)
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D0: thin layer / 10–15 min soak → repair → SPF/shade
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D1: same as D0 (thin layer once is enough)
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D2: repair-first; optional thin layer if needed
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D3: consider low-% niacinamide or gentle peptides
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D4–D5: maintain hydration + repair
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D6–D7: another thin layer/soak if desired; prep next week
If at any point you have persistent burning, broad swelling/redness, or weeping, stop all functional actives. Use saline + repair only, and seek medical care if needed.
Quick FAQ
Q: I have steroid-damaged/rosacea-prone redness. Can I use this?
A: Patch test first. Use in stable periods under professional guidance, favoring non-invasive thin-layer/soak. Avoid self-directed high-intensity procedures.
Q: Can I use it daily?
A: Not recommended. Sensitive skin thrives on rhythm and tolerance. 1–2×/week is typically enough. Microneedling/energy sessions still follow every 7–10 days.
Q: Should I use a device for infusion?
A: Prefer hand application + soak. If using a tool, keep it low-heat/low-intensity and only under professional assessment.
Q: Can I use it with prescribed meds?
A: Follow your physician first. If you’re on Rx treatment, consult your doctor before adding any functional skincare.
Fixed compliance note (drop-in for your site)
Our products are cosmetics for surface-level skincare—soothing, hydration, and barrier support. They are not intended to diagnose, treat, cure, or prevent disease. Sensitive users should patch test and follow professional guidance.
One-line wrap
Sensitive skin isn’t about “using more”—it’s about using steadily and cleanly. With freeze-dry + fresh-mix, a skin-like diluent, and Fresh-Batch 48h traceability, you reduce variables from end to end. Add the patch-test → first use → consolidation sequence, and you’ll keep soothing and barrier support on a low-irritation track, week after week.
Read more
In 2013, the Nobel Prize in Physiology or Medicine established the cellular “vesicle trafficking” mechanism—essentially the instruction manual for how cells package and deliver signals. That insig...
Our cautious stance for special periods In 2013, the Nobel Prize in Physiology or Medicine established the cellular “vesicle trafficking” mechanism—essentially the instruction manual for how cells ...





