Follow the “Low-Heat, Low-Power, Controllable” rule

The 2013 Nobel Prize showed how cells ship cargo in tiny vesicles. That playbook lets us understand and control exosome production and release, opening big possibilities in skincare and aesthetics. Exosomes are now seen as one of this century’s key ways to advance regeneration and repair.

 

 

• Yes, you can pair—but only under “Low-Heat, Low-Power, Controllable.” Prioritize LED, cold mist/cooling, and gentle physical infusion.

• Thermal/energy devices (RF, HIFU, high-power ultrasound) must follow your clinic’s SOP for timing and intensity.

• Order of operations: Do the procedure → cool/let skin close → reconstitute EXO-Lyospheres™ and apply → 10–15 min calming mask → (optional) low-intensity add-ons (LED/light infusion).

• At home: stick to low-intensity LED and hand application/soak-mask. Avoid strong energy, any “breaking the skin,” or heat-heavy gadgets.

 

 

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1) What pairs best? (from gentlest to more cautious)

 

 

• LED (red/near-IR preferred): low heat, physical light only; great post-cooling for calming.

• Cold mist / cool packs / isotonic soaks: the post-procedure basics for cooling + hydration.

• Low-intensity physical infusion (iontophoresis/microcurrent/light ultrasound): clinic-only, low setting, short duration, no obvious heat.

• High-energy / thermal devices (RF, Thermage®, HIFU, high-power ultrasound): do not stack in the same sitting with this product. Use only after heat has resolved and epidermis is intact (often 2–6 h later or D1) per SOP.

 

Our format: EXO-Lyospheres™ lyophilized powder + dedicated solvent. One vial = one session, reconstitute immediately before use. If you must split, refrigerate 2–8 °C and finish within 48 h.

 

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2) Timing matrix

 

Upstream procedure	Skin status needed	When to apply EXO-Lyospheres™	Optional pairing (suggested)
Microneedling/dermarolling (0.25–0.5 mm)	Cooled, epidermis intact	D0: within 0–60 min → calming mask 10–15 min	Low-intensity LED (short), or gentle infusion (after evaluation)
IPL / low–mid energy lasers	Heat resolved	D0: 30–60 min after cooling	LED/cold mist first; infusion only low setting, short
Non-ablative fractional	Microchannels + heat	6–24 h or D1	Start with LED/cooling; gentle infusion later if cleared
Ablative fractional (CO₂ / Er:YAG)	Re-epithelialized	D2–D3 after stable closure	LED/cooling first; delay infusion further
RF / Thermage® / HIFU	Deep heat, intact epidermis	D0: 2–6 h or D1 (after heat resolves)	LED first; any infusion = low setting, short

Always: Procedure → cool/close → EXO-Lyospheres™ → calming mask → (optional) gentle add-on.

If skin still feels hot or exudes fluid the same day, delay 24 h.

 

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3) Standard pairing workflow (clinic)

 

 

1. Finish procedure → cool 10–20 min, confirm epidermal integrity.

2. Reconstitute: add the dedicated solvent down the vial wall; gently invert (no hard shaking).

3. Apply: thin, sectional application; one vial = full face.

4. Calm: 10–15 min soothing mask.

5. Optional: LED (low intensity, short). If using an infusion device: lowest effective level, 1–2 min per zone, total ≤10–15 min, no overt heat/sting.

6. Finish: light barrier cream + broad-spectrum/physical-leaning SPF.

 

 

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4) At-home guidance: what we advise vs. avoid

 

Do

 

• Low-intensity LED, short sessions (follow device manual).

• Hand application/soak-mask with EXO-Lyospheres™ (non-invasive only).

• 72-hour rule: repair + SPF; shade first.

 

Don’t

 

• High-power ultrasound/RF/electroporation/“infusion guns”.

• Stack with acids/strong retinoids/high-dose L-AA the same night.

• Home microneedling (see Q8).

 

 

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5) Do & Don’t (quick check)

 

Do

 

• Choose low-heat, low-power, controllable add-ons (LED/gentle infusion).

• If any device is used: no obvious heat or stinging.

• Same-day: skip makeup and heavy/water-resistant sunscreens (see Q14).

 

Don’t

 

• Add infusion or another heat device right after a thermal procedure.

• Stack multiple machines “for speed.”

• Reconstitute with third-party liquids (use dedicated solvent only, see Q29).

 

 

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6) FAQs

 

LED before or after EXO-Lyospheres™?

Either. If residual warmth persists, LED first to settle heat, then apply.

Is ultrasound infusion always better?

Not necessarily. Power and heat matter—gentle and short beats “stronger/longer.”

Do I need polarities for iontophoresis?

We don’t recommend complex polar programs in the post-procedure window. If used, keep low current, short time, and stop if any sting.

Can I use a beauty device daily at home?

Not within 72 h post-procedure. Prioritize repair + SPF. Start low and space out based on tolerance.

 

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7) Aligned with our “PURE” principles

 

 

• Pure Use: Cosmetic-grade, surface care only—soothing, hydration, barrier support.

• Pure Form: Lyophilized + dedicated solvent, one vial = one session to limit contamination.

• Pure Trace: Fresh-Batch 48h fulfillment and per-vial traceability (LOT / Vial-ID / Trace Page) make every pairing auditable.

 

 

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Compliance note

This product is a cosmetic for surface use only. It is not intended to diagnose, treat, or prevent disease. Energy-device use must follow professional evaluation and clinic SOPs. At home, avoid high-energy and any skin-breaking tools.

 

One-line wrap-up

 

Cool the procedure, apply exosomes steadily, then—if you add anything—keep it low-heat, low-power, and tightly controlled. Following sequence and timing beats piling on more devices every time.