Q30｜Why is it slightly cloudy or bubbly after reconstitution?

Understanding Appearance After Reconstitution

When you mix the lyophilized exosome powder with the activating solution, the resulting colloidal dispersion may appear slightly cloudy or contain tiny bubbles. This is normal and due to the nanoscale exosome particles scattering light and small air pockets introduced during mixing.

Normal Appearance

• A faint milky or opalescent look is expected; it results from the Tyndall effect in a nano-dispersion.
• Tiny air bubbles may form during mixing; they usually dissipate after a few minutes or with gentle inversion.

When to Be Cautious

• Discontinue use if you observe significant discoloration (yellow, brown, green), unusual odors, or visible particles that do not re-disperse.
• Do not use if seals are broken or there are leaks.

Science Background

Exosomes are nano-sized vesicles carrying proteins, lipids, and RNAs. Nobel Prize-winning research on vesicle transport (2013) and microRNAs (2024) underpins our understanding of exosome stability (Vesicle Discovery Wins Nobel for Medicine | Exosome RNA, MicroRNAs won the Nobel Prize. Now, can extracellular vesicles …). Because exosomes form colloidal dispersions, slight cloudiness is inherent to the formulation.

Safe Handling

• Mix gently by swirling; avoid vigorous shaking which introduces excessive air.
• Allow the serum to rest for 1‑2 minutes after mixing to let bubbles settle.
• Use the serum immediately and do not store the mixture.
• Use externally only; our products are cosmetics, not drugs, and the FDA has not approved exosome therapies (The real science of exosomes—the latest obsession in skincare).