Only use the paired diluent. “Looks-fine” substitutes aren’t fine.
2013’s Nobel Prize in Physiology or Medicine decoded cellular “vesicle trafficking.” That blueprint informs how we handle exosomes today—why a purpose-built diluent matters for stability, comfort, and hygiene.
TL;DR
No. Reconstitute EXO-Lyospheres™ freeze-dried vials only with the paired diluent. Purified water, mineral water, medical saline, toners, or any third-party liquid are not suitable and raise risks for stability, irritation, and contamination.
Why the
paired diluent
is non-negotiable
Our diluent is not “just water.” It’s formulated for the freeze-dried exosome matrix: isotonic, skin-friendly weak-acid pH, gently buffered, and manufactured under tight purity controls. Goal: keep reconstituted solution stable, comfortable, and hygienic during its 48-hour in-use window.
What goes wrong with “almost” diluents
-
pH drift: Pure water/saline have no buffer → pH swings → more sting/tightness.
-
Osmotic mismatch: Non-isotonic media stress vesicles → flocculation/precipitation, skewed payload profile.
-
Protein/peptide stress: No stabilizing environment → aggregation or loss of activity after mixing.
-
Bioburden/endotoxin risk: Non-paired sources or cross-container handling increase contamination risk.
-
Traceability lost: Deviating from IFU breaks the quality loop and complicates root-cause analysis.
-
Feel & safety unpredictable: Wider irritation variance; poor fit for the post-procedure window.
The correct workflow (quick guide)
-
Prep: Clean hands & surface. Get one freeze-dried vial + its paired diluent.
-
Reconstitute: Run diluent down the vial wall to the mark—no splashing.
-
Mix: Gently invert 5–10× (do not hard-shake/foam).
-
Use on time: For microneedling/device days, apply within 0–60 min post-procedure → calming mask 10–15 min.
-
One vial = one session. If you must split, refrigerate 2–8 °C and finish within 48 h (see Q11).
-
Abort if off: Stop using if you notice odor, marked discoloration, stringy/flocculent precipitate, or a broken seal; contact support.
Do & Don’t (at a glance)
|
Item |
✅ Do |
❌ Don’t |
|---|---|---|
|
Reconstitution liquid |
Paired diluent only |
Purified/medical saline/mineral water/toner/any third-party liquid |
|
Mixing method |
Gentle inversion to clarify |
Hard shaking, vigorous vortexing, foaming |
|
Hygiene |
One vial per session; cap promptly |
Pool vials, decant across containers, leave uncapped |
|
Timing |
0–60 min post-procedure |
Reconstitute hours later, then rush application |
|
Storage (if split) |
2–8 °C, finish within 48 h |
Freeze; leave in a hot car; keep at room temp overnight |
Aligned with our
PURE
principles
-
Pure Form — Freeze-dry + paired diluent = peak freshness at use.
-
Pure Use — Isotonic, weak-acid pH, buffered environment tailored for the sensitive post-procedure window.
-
Pure Trace — Fresh-Batch 48h (newest released lot, per-vial label, temperature-controlled ship). LOT / Vial-ID link to the Trace Page. Deviations from IFU break traceability.
FAQ
Isn’t medical saline safer?
Not for this system. Saline lacks buffering; while osmolarity is near physiologic, it’s not optimized for vesicle integrity or skin feel here.
Can I mix with my clinic’s import serum or conductive gel?
Don’t mix. Co-formulation shifts pH/osmolality/solvent polarity and invalidates stability and safety assumptions.
I see a few tiny bubbles after mixing—problem?
Usually fine. Let it stand 1–2 minutes. Avoid vigorous shaking that creates foam.
Can I split one vial for two days?
Best practice is one vial = one session. If you must: refrigerate 2–8 °C and finish within 48 h, keeping handling as closed and clean as possible.
Compliance footer (site-ready)
This is a cosmetic product for surface-level soothing, hydration, and barrier support. It does not diagnose, treat, cure, or prevent disease. Reconstitute only with the paired diluent. Using third-party liquids introduces unassessed stability and safety risks and voids traceability.
One-line wrap
For exosomes, doing reconstitution right beats doing more: paired diluent, gentle mixing, one vial per session, 48-hour in-use rule—lock in stability, comfort, and traceability in one move.
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