Q12｜What Can I Pair It With

Aug 30, 20254 min read

Same Day, First 72 Hours, and One-Week Pairing Cheatsheet

In 2013, the Nobel Prize in Physiology or Medicine established the cellular “vesicle trafficking” mechanism—essentially the instruction manual for how cells package and deliver signals. That insight helps us understand and modulate exosome formation and release, opening possibilities in skin and aesthetic care. Exosomes have since been widely explored as one of the most promising ways to break long-standing bottlenecks in regeneration and repair.

TL;DR

D0 (procedure day): gentle cleanse → freshly reconstituted exosomes (full vial) → 10–15 min calming mask → repair cream → broad-spectrum/physical SPF.
D1–D3 (first 72 h): hydrate + repair only; avoid strong acids/exfoliants, high-% L-AA vitamin C, strong retinoids, high alcohol/strong fragrance.
D4–D7: re-introduce low-intensity actives (e.g., low-% niacinamide, peptides, gentle antioxidants).
≥D7: cautiously re-introduce stronger actives (acids/retinoids/high-% L-AA) at low dose & low frequency first.

Our format is EXO-Lyospheres™ (freeze-dried powder + dedicated diluent). One vial = one session. Rhythm: every 7–10 days. Pro/Max/Ultra cover 1/2/3 sessions. Fulfillment: Fresh-Batch 48h with per-vial traceability.

01｜D0 “Can / Can’t” at a glance

Category	Pair on D0?	Notes
Gentle cleanser (amino-acid type)	✅	<30 s, lukewarm water; avoid brushes/scrubs
Exosomes (fresh-mix, full vial)	✅	Core step: apply within 0–60 min post-microneedling
Calming mask / isotonic mist	✅	10–15 min; avoid alcohol/strong fragrance
Repair cream (ceramides/squalane/cholesterol/panthenol)	✅	Thin seal; minimalist formulas preferred
Sunscreen (broad-spectrum/physical priority)	✅	Apply before leaving clinic
AHA/BHA/strong exfoliants	❌	Raises irritation/PIH risk
High-% L-AA vitamin C (≥15%)	❌	Low pH, higher sting—skip on D0
Retinoids (retinol/retinal/Rx tretinoin)	❌	Avoid same-day stacking with microneedling
High alcohol/strong perfume/essential oils	❌	Minimize triggers on D0

02｜D1–D3 (first 72 h): how to build the stack

Skeleton: gentle cleanse → thin layer of freshly mixed exosomes → HA/polysaccharide hydrator → repair cream → broad-spectrum SPF.

Nice-to-haves: low-% niacinamide (2–5%), peptides, chitosan/fructans (gentle AOX/hydration).

Still avoid: AHA/BHA, scrubs/at-home peels, high-% L-AA, strong retinoids, at-home RF/high-heat infusion, heavy fragrance/high alcohol toners.

03｜D4–D7: low-intensity return (go

light

before

more

)

Safer first steps

Vitamin C derivatives (e.g., Ascorbyl Glucoside / 3-O-Ethyl) at low %
PHA/lactobionic acid 1×/week to start
Peptides (e.g., copper peptides/oligopeptides)

Still cautious

AHAs (glycolic/lactic): start low %, 1×/week, then watch 48 h
Retinoids: retinol ≤0.1% to start, alternate nights
High-% L-AA: reassess ≥D7

04｜≥D7: bring back “the big guns” by tolerance

Retinoid track: retinol 0.1% → alt-night → nightly over 2–4 weeks, then consider 0.3–0.5%.
Acids track: PHA → low-% AHA; start 1×/week; do not stack in the same week as microneedling.
Vitamin C track: L-AA 10–15% to start; time-split with exosomes (AM = C, PM = exosomes) or alternate nights.

Rule: add one potent active at a time; observe 3–7 days before adding the next.

05｜Pairing mini-playbooks by skin context

Dry-sensitive / seasonal shift: D1–D7 stick to exosomes + repair; ≥D7 add low-% niacinamide/peptides.
Oily/congestion-prone: avoid acids in the first 72 h; ≥D7 introduce PHA or low-dose salicylic as patch/zone care—skip full-face peels in the microneedling week.
Early aging/fine lines: D4–D7 lean on peptides; ≥D7 introduce low-% retinoid, time-split with exosomes.
PIH-prone: sun control is king—broad-spectrum/physical SPF and shade. Slow the re-entry of acids/retinoids by one notch.

06｜How to layer smartly (time, zone, cycle)

By time: exosomes at night (aligns with SOP); AM focuses on antioxidants/SPF.
By zone: T-zone (oil/keratinization) resumes PHA first; U-zone stays repair-heavy; spot high actives only where needed.
By cycle: Microneedling week = stabilization only; non-microneedling week = re-introduce actives.

07｜A ready-to-use 7-day template

D0: microneedling → fresh-mix exosome full vial → 10–15 min calming mask → repair cream → broad-spectrum/physical SPF
D1: cleanse → thin exosome layer → HA → repair → SPF
D2: same as D1 (optional low-% niacinamide 2–5%)
D3: same as D1 (PM add gentle peptides)
D4: cleanse → AM low-% vitamin C derivative / PM peptides → repair → SPF
D5: optional PHA at night (full face or T-zone); keep the rest repair-focused
D6: reset day (repair + SPF)
D7: assess tolerance; consider re-introducing low-% retinoid or low-% AHA (time-split with exosomes)

08｜Makeup, tools & devices

Makeup: wait 48–72 h; start with oil-free SPF + concealer; postpone heavy makeup.
Beauty devices/LED: low-heat, low-intensity red LED can be used D1–D3 if comfortable; RF/high-heat infusion ≥D7.
Infusion gadgets: keep low intensity and non-irritating; priority remains fresh-mix exosomes + calming occlusion.

09｜Quick FAQ

D0 with vitamin C/A together? Not advised—reassess after 72 h.
No microneedling—just weekly stabilization? Cleanse → thin exosome layer/soak 1–2×/week → repair → SPF; keep the rest of your routine normal.
Exosomes + my peptide/copper peptide serum? Yes—add D3–D7 gradually; avoid heavy same-night stacking with strong acids.
Physical SPF mandatory? Strongly preferred in the first 72 h. If you sweat a lot, a gentle chemical SPF can be used—but shade/avoidance takes priority.

One-line wrap

Hit the D0 window, make the 72 h rock-solid, and stagger the heavy hitters back in. Exosomes then play nicely in your routine—soothing, hydrating, and barrier support without fights—so you can scale down or level up with control.

Compliance & scope note (drop-in for your site)

Our products are cosmetics for surface-level skincare—hydration, soothing, and supporting the skin barrier. They are not intended to diagnose, treat, cure, or prevent any disease. On-site research/case content is educational and not an individual performance guarantee or medical advice. Always follow professional guidance for in-clinic procedures and aftercare.

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