Q13｜Can I Pair It with Laser, RF, IPL, etc.?

Time Windows & How-To by Energy Modality

In 2013, the Nobel Prize in Physiology or Medicine established the cellular “vesicle trafficking” mechanism—essentially the instruction manual for how cells package and deliver signals. That insight helps us understand and modulate exosome formation and release, opening possibilities in skin and aesthetic care. Exosomes have since been widely explored as one of the most promising ways to break long-standing bottlenecks in regeneration and repair.

 

---

 

 

TL;DR

 

Yes—pairing is appropriate as a post-procedure topical for soothing and barrier support. It is not a medical treatment claim.

 

• Heat-based (RF/Thermage/HIFU): wait until heat subsides and the surface is intact—often 2–6 h same day or D1.

• Fractional / lasers / IPL: device first → cool/settle/epithelialize → exosomes. Timing follows your clinic SOP.

 

Format: EXO-Lyospheres™ freeze-dried exosomes + dedicated diluent. One vial = one session, fresh-mix at use, then 10–15 min calming mask.

 

---

 

 

1) Recommended time windows by procedure

 

Modality	Wound/heat profile	First exosome window (reference)
IPL / Photofacial	Non-ablative, moderate heat	D0: after 30–60 min cooling and once heat has settled, thin layer
Picosecond / Q-switched (low–mid fluence)	Non-ablative, transient heat	D0: within 0–60 min after heat subsides; heavy erythema → D1
Non-ablative fractional (1550/1927)	Micro-channels + heat	6–24 h or D1; prioritize isotonic calming on the evening of D0
Ablative fractional (CO₂ / Er:YAG)	Micro-ablation / crusting	D2–D3 after re-epithelialization begins; first 24–48 h = isotonic + barrier only
RF microneedling	Needling + heat	6–24 h or D1 (after heat resolves)
Monopolar/Multipolar RF (e.g., Thermage)	Deep heat, intact surface	D0 2–6 h or D1 once heat clears
HIFU	Deep focal heat, intact surface	D0–D1: thin layer after tenderness eases

Principle: device → cool/stop heat → fresh-mix exosomes → calming occlusion. If notable burning/exudate persists, delay 24 h.

 

---

 

 

2) Standard pairing flow (chairside)

 

 

1. Cool & settle 10–20 min (isotonic mist / cooling pack).

2. Check epidermis: no active ooze; surface intact.

3. Reconstitute: run diluent down the vial wall, gently invert to clear (no hard shaking/foaming).

4. Apply: zone-by-zone thin dots + light pressing; face = one vial standard dose.

5. Occlude to calm: 10–15 min calming sheet.

6. Finish: minimalist barrier cream; broad-spectrum/physical SPF before discharge.

7. First 72 h: thin-layer exosomes + barrier support; avoid strong acids, high-% L-AA vitamin C, strong retinoids, and high-heat devices.

 

 

---

 

 

3) Dose & zoning (face reference)

 

 

• Total: ≈ 10 B per full face; for larger areas/deeper goals a professional may tune toward ≈20 B.

• Distribution: forehead 15–20% | cheeks 50–60% | nose 10–15% | jawline/nasolabial 15–20%.

• One vial = one use. If splitting is unavoidable: refrigerate 2–8 °C and finish within 48 h.

 

 

---

 

 

4) D0–D3: Do & Don’t

 

Do

 

• Isotonic mist; 10–15 min calming sheet mask

• Ceramide/squalane/cholesterol/panthenol low-irritation repair cream

• Broad-spectrum/physical SPF and physical shade outdoors

 

Don’t

 

• AHA/BHA peels, strong scrubs, high-% L-AA, strong retinoids on the same day

• Stack hot energy again (RF→RF, HIFU→HIFU) immediately after

• Apply actives over oozing/open surface or use high-alcohol toners

 

 

---

 

 

5) Sample weekly planner (mixing modalities)

 

 

• Mon: Non-ablative fractional → D0 6–24 h or D1 exosomes

• Thu: RF microneedling → D1 exosomes consolidation

• Sun: Recovery day → exosomes + repair; skip strong acids/retinoids this week

 

For rolling microneedling programs, keep every 7–10 days; Ultra (3+3) maps cleanly to a 3–4 week condensed cycle.

 

---

 

 

6) Red lines & referral signals

 

 

• 24–48 h persistent burning, broad exudate, or intense pruritus → stop all functional actives; isotonic + repair only; consider clinic review.

• Infection signs (pustulation/fever) → seek medical care promptly.

• PIH-prone individuals: strict photo-protection; slow the re-entry of acids/retinoids.

 

 

---

 

 

7) How this aligns with our delivery & traceability

 

 

• Fresh-Batch 48h: within 48 h of order we allocate the latest released batch, print per-vial labels, and ship temperature-aware.

• EXO-Lyospheres™: freeze-dried + dedicated diluent, fresh-mix to match the post-energy time window.

 

 

---

 

 

8) Quick FAQ

 

Q: Can I apply the same day after Thermage?

A: Yes—once heat fully subsides and the surface is intact, often 2–6 h post-procedure or D1.

Q: CO₂ fractional—same day okay?

A: Not advised. Use isotonic + barrier first; D2–D3 evaluate thin exosome layering after stable re-epithelialization.

Q: Sequence for RF microneedling + exosomes?

A: RF-MN first, exosomes 6–24 h later or D1, once heat settles.

Q: Pair with cold spray/LED?

A: Yes. Exosome fresh-mix → calming sheet 10–15 min is a solid combo. High-heat devices should wait ≥D7.

 

---

 

 

One-line wrap

 

Match the energy type and wound depth to the exosome “golden window”: device first, cool/close, then fresh-mix exosomes. Follow the tabled timing and the one vial = one use rule to consistently land soothing, hydration, and barrier support—without crossing medical claim lines.

 

---

 

 

Compliance & scope note (drop-in for your site)

 

Our products are cosmetics intended for surface-level skincare—hydration, soothing, and supporting the skin barrier. They are not intended to diagnose, treat, cure, or prevent any disease. Any research/case materials on this site are for educational context only and do not constitute individual performance guarantees or medical advice. Always follow local regulations and your clinic’s SOP.